Orji, Oliver C;
López-Domínguez, Maria B;
Sandoval-Plata, Gabriela;
Guetta-Baranes, Tamar;
Valdes, Ana M;
Doherty, Michael;
Morgan, Kevin;
Abhishek, Abhishek
Upregulated expression of FFAR2 and SOC3 genes is associated with gout
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Medientyp:
E-Artikel
Titel:
Upregulated expression of FFAR2 and SOC3 genes is associated with gout
Beteiligte:
Orji, Oliver C;
López-Domínguez, Maria B;
Sandoval-Plata, Gabriela;
Guetta-Baranes, Tamar;
Valdes, Ana M;
Doherty, Michael;
Morgan, Kevin;
Abhishek, Abhishek
Erschienen:
Oxford University Press (OUP), 2023
Erschienen in:Rheumatology
Sprache:
Englisch
DOI:
10.1093/rheumatology/keac360
ISSN:
1462-0324;
1462-0332
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Objective</jats:title>
<jats:p>To examine the expression of Free fatty acid receptor 2 (FFAR2) and Suppressor of cytokine signalling 3 (SOCS3) genes in asymptomatic hyperuricaemia (AH), AH with MSU crystal deposition, inter-critical gout and gout flare.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods</jats:title>
<jats:p>Study participants (n = 120) comprised 34 people with serum urate (SU) &lt;360 μmol/l, 69 with AH ± MSU crystal deposition and 17 with a gout flare. Sixteen of the 17 patients with a gout flare attended a second visit 6–12 weeks later. Gene expression levels were assessed using RT-qPCR and results computed as fold changes (FC) after normalization to the reference gene.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results</jats:title>
<jats:p>FFAR2 was significantly upregulated during gout flares (FC = 2.9) compared with normal SU, AH, and AH + MSU crystal deposition (FC = 1.1, P &lt; 0.0001 for each comparison). FFAR2 was also significantly upregulated during inter-critical gout (FC = 1.8) compared with normal SU, AH and AH + MSU (FC = 1.1, P &lt; 0.001 for each comparison). SOCS3 was significantly upregulated during gout flares (FC = 3.4) compared with normal SU, AH, and AH + MSU crystal deposition (FC = 1.1, 1.1 and 1.2, respectively, P &lt; 0.0001 for each comparison). SOCS3 was also upregulated during inter-critical gout (FC = 2.1) compared with normal SU (P = 0.02) and AH (P = 0.006) (FC = 1.1 and 1.2, respectively). FFAR2 expression was upregulated during gout flare compared with inter-critical gout and SOCS3 expression showed negative correlation with flare duration (r = –0.49, P &lt; 0.05).</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>FFAR2 upregulation is associated with gout and may trigger gout flares. SOCS3 may have a role in amelioration of gout flares.</jats:p>
</jats:sec>