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Medientyp:
E-Artikel
Titel:
Leptin and adiponectin are both suppressed upon activation of Nucleotide Oligomerization Domain Containing Protein 1 during adipocyte differentiation
Beschreibung:
<jats:p>Obesity is associated with chronic inflammation. Toll‐like receptors (TLR) and NOD‐like receptors (NLR) are two families of pattern recognition receptors that play important roles in inflammation in adipocytes. It has been reported that TLR4 and TLR2 activation induce proinflammatory changes that impair adipocyte differentiation. However, the effects of activation of NOD1 and NOD2, the two prominent members of NLR, on adipocyte differentiation have not been studied. Here we report that activation of NOD1, but not NOD2, by the synthetic ligand dose‐dependently suppresses 3T3‐L1 adipocyte differentiation as revealed by oil red O stained cell morphology, attenuated genes expression of adipocyte markers and lipid accumulation. However, both NOD1 and NOD2 activation significantly suppress the differentiation of primary preadipocytes derived from human subcutaneous fat. In contrast to TLR4 activation, NOD1 activation suppresses both adiponectin and leptin in adipocytes, demonstrating differential effects of NOD1 activation on adipocytes. Overall, our results support that NOD1 represents a novel target for obesity prevention and/or treatment. The work is supported by The University of Tennessee faculty start‐up funds to LZ.</jats:p>