Cardon, Brandon R.;
Stallings, Michael T.;
Brunson, Scott E.;
Hart, Chris M.;
Swiss, Maria D.;
Hepworth, Squire D.;
Christensen, Merrill J.;
Hancock, Chad R.
Dietary isoflavones and supplemental selenium show interactive effects on blood‐glucose homeostasis in male FVB mice
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Medientyp:
E-Artikel
Titel:
Dietary isoflavones and supplemental selenium show interactive effects on blood‐glucose homeostasis in male FVB mice
Beteiligte:
Cardon, Brandon R.;
Stallings, Michael T.;
Brunson, Scott E.;
Hart, Chris M.;
Swiss, Maria D.;
Hepworth, Squire D.;
Christensen, Merrill J.;
Hancock, Chad R.
Beschreibung:
Isoflavones and supplemental selenium have shown interactive effects on body weight, body fat, and blood‐glucose homeostasis. To further elucidate the effects of the interaction, FVB mice were fed either high or low‐isoflavone (HIF or LIF) diets, with or without supplemental selenium. Custom diets were designed to be equivalent in vitamin, mineral and amino acid profiles, but to differ in soy protein and specific isoflavone content. The HIF diet was tested to ensure 500mg/kg aglycone equivalents of genistein + daidzein. Selenium was administered by gavage daily (3mg/kg body wt/day) as Se‐methylselenocysteine, either from conception (Sel‐C), or weaning (Sel‐W). All groups were compared against a LIF‐no‐Sel control group. After 5 months HIF‐Sel‐W mice had elevated fasting glucose levels (HIF‐no sel 106.2 ± 2.76, HIF‐Sel‐W 121.6 ± 2.79 mg/dL, p=.008). LIF‐Sel‐W mice followed the same trend, but values were not significant (p=.109) Homeostatic Model Assessment of Insulin Resistance showed a 274% ± 36% increase of insulin resistance in the LIF‐Sel‐C group (p=.034), but not in HIF groups. Although blood‐glucose and insulin levels were affected by treatments, body weights and abdominal fat pads were not different, contrary to findings in other models. These results demonstrate an interactive effect of dietary isoflavone content and supplemental selenium on glucose regulation in the absence of changes in body fat.