Beschreibung:
Thyroid follicular adenoma (FA) is a benign tumor of the thyroid gland where cells produce iodine‐containing hormones. FA can precede either follicular carcinoma or papillary carcinoma. To discover the molecular mechanism involved in follicular adenoma, diseased and matched normal adjacent tissue were analyzed by liquid chromatography tandem mass spectrometry (LC‐MS/MS). Using a label‐free quantitative mass spectrometry‐based proteomics approach, IdentiQuantXL, 1,799 unique, non‐redundant proteins were compared between FA and normal tissue samples. Among the 1,799 proteins, 15 proteins had significant changes (p ¡Ü 0.05) between the two groups. Using Ingenuity Pathways Analysis (IPA), their molecular and cellular functions were discovered, including cell‐to‐cell signaling and interaction, cell cycle, cell death and survival, cell morphology, and cellular assembly and organization. Among the 15 proteins, 6 proteins were cancer‐related. In conclusion, differential protein expression was observed, which may reveal the mechanism in the development of follicular adenoma.