Beschreibung:
<jats:p>Emerging evidence suggests that exposure to endocrine disruptors may initiate or exacerbate adiposity and associated health problems. This study examined the associations of urinary levels of bisphenol‐A (BPA) and phthalates with several adiposity‐related conditions among U.S. adults, namely, obesity, insulin resistance and metabolic disturbances. Secondary data analyses were performed using a sample of 3,566 participants from the 2005–2008 National Health and Nutrition Examination Surveys. Levels of BPA and 15 phthalate metabolites were defined in quartiles. Multivariate linear and logistic regression models for the hypothesized relationships were constructed after controlling for age, sex, race, education, marital status, smoking status, physical activity, total dietary intake and urinary creatinine level. BPA was positively associated with body mass index and negatively associated with high density lipoprotein cholesterol and diastolic blood pressure. Moreover, a positive relationship was observed for BPA level with triglycerides ≥ 150 mg/dL and insulin resistance. By contrast, total phthalates were not associated with the outcomes of interest after controlling for confounders. Prospective cohort studies are needed to examine BPA and phthalates as determinants of obesity, insulin resistance and other adiposity‐related conditions.</jats:p><jats:p><jats:bold><jats:italic>Grant Funding Source</jats:italic></jats:bold><jats:italic>: None</jats:italic></jats:p>