Beschreibung:
<jats:p>Vascular dysfunction is a significant cardiovascular disease (CVD) risk factor. High fat meals tend to incur a postprandial loss of vascular reactivity, with our previous work showing that the inclusion of fish oil, providing the long chain n‐3 PUFA, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in part ameliorated the response. In this randomised placebo controlled crossover study (n=25), the individual impact of EPA versus DHA (4.2g) on postprandial vascular reactivity in males aged 35‐55 years old at 1.5 relative risk of CVD was assessed, along with underlying physiological mechanisms.</jats:p><jats:p>Both EPA and DHA improved the postprandial vascular augmentation index by 16.7% and 15.8% respectively, with the effect for DHA but not for EPA reaching significance. In addition to the vascular measures, a range of biochemical markers of vascular function and lipidomic analyses will be presented. The trial advances currently understanding of the individual vascular benefits of EPA vs. DHA and the relative impact of these fatty acids on overall cardiovascular health.</jats:p>