Beschreibung:
<jats:p>Chronic obstructive pulmonary disease (COPD) and Type 2 Diabetes Mellitus (T2D) are among the 10 leading causes of death in the US. 14‐15% of COPD patients admitted to the hospital have T2D. PH is a common complication of COPD, but there is limited data on the prevalence of PH in patients who also have T2DM. There is very little literature on the impact EX may have on these patients. The study objective study was to determine the effect of EX training on glycemic control and skeletal muscle function in T2D with PH. 12‐week old, male obese Zucker (O) and lean, age‐matched Zucker controls (L) were used in this study. Rats were randomized into EX (15m/min; 20<jats:sup>o</jats:sup> slope) or sedentary groups and were given a dose of monocrotaline (40 mg/kg bw) to induce PH or saline placebo. The EX intervention lasted 8 weeks. At 8 weeks, animals were fasted overnight and plasma and tissues were collected. There was no difference in total weight gain and final body weight in rats within the O or L groups. There was significant difference (<jats:italic>P</jats:italic><0.05) between final O and L body weights and weight gain. O had lower (<jats:italic>P</jats:italic><0.05) muscle mass than L. There was a trend for EX to reduce body fat in both groups. There was no difference in fasting insulin or glucose between treatments, however there a trend for higher values in O. O with PH and EX had higher (<jats:italic>P</jats:italic><0.05<jats:italic>)</jats:italic> plasma levels of leucine, isoleucine and valine than sedentary. In conclusion, aerobic exercise training does not impact body composition or glycemic control in T2D with PH. Funded by Arkansas Biosciences Institute.</jats:p>