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Li, Daniel; Jia, Angela Y.; Zorzi, Jane; Griffith, Paige; Kim, Amy K.; Dao, Doan; Anders, Robert A.; Georgiades, Christos; Liddell, Robert P.; Hong, Kelvin; Azad, Nilofer S.; Ho, Won Jin; Baretti, Marina; Christenson, Eric; Baghdadi, Azarakhsh; Kamel, Ihab R.; Meyer, Jeffrey; Ghabi, Elie; Burkhart, Richard A.; Lafaro, Kelly; He, Jin; Shubert, Chris; Yarchoan, Mark

Impact of the COVID-19 Pandemic on Liver Cancer Staging at a Multidisciplinary Liver Cancer Clinic

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  • Medientyp: E-Artikel
  • Titel: Impact of the COVID-19 Pandemic on Liver Cancer Staging at a Multidisciplinary Liver Cancer Clinic
  • Beteiligte: Li, Daniel; Jia, Angela Y.; Zorzi, Jane; Griffith, Paige; Kim, Amy K.; Dao, Doan; Anders, Robert A.; Georgiades, Christos; Liddell, Robert P.; Hong, Kelvin; Azad, Nilofer S.; Ho, Won Jin; Baretti, Marina; Christenson, Eric; Baghdadi, Azarakhsh; Kamel, Ihab R.; Meyer, Jeffrey; Ghabi, Elie; Burkhart, Richard A.; Lafaro, Kelly; He, Jin; Shubert, Chris; Yarchoan, Mark
  • Erschienen: Ovid Technologies (Wolters Kluwer Health), 2022
  • Erschienen in: Annals of Surgery Open
  • Sprache: Englisch
  • DOI: 10.1097/as9.0000000000000207
  • ISSN: 2691-3593
  • Schlagwörter: General Earth and Planetary Sciences
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec> <jats:title>Objectives:</jats:title> <jats:p>To compare liver cancer resectability rates before and during the COVID-19 pandemic.</jats:p> </jats:sec> <jats:sec> <jats:title>Background:</jats:title> <jats:p>Liver cancers usually present with nonspecific symptoms or are diagnosed through screening programs for at-risk patients, and early detection can improve patient outcomes. In 2020, the COVID-19 pandemic upended medical care across all specialties, but whether the pandemic was associated with delays in liver cancer diagnosis is not known.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>We performed a retrospective review of all patients evaluated at the Johns Hopkins Multidisciplinary Liver Cancer Clinic from January 2019 to June 2021 with a new diagnosis of suspected or confirmed hepatocellular carcinoma (HCC) or biliary tract cancer (BTC).</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>There were 456 liver cancer patients (258 HCC and 198 BTC). From January 2019 to March 2020 (pre-pandemic), the surgical resectability rate was 20%. The subsequent 6 months (early pandemic), the resectability rate decreased to 11%. Afterward from October 2020 to June 2021 (late pandemic), the resectability rate increased to 27%. The resectability rate early pandemic was significantly lower than that for pre-pandemic and later pandemic combined (11% lower; 95% confidence interval [CI], 2%–20%). There was no significant difference in resectability rates pre-pandemic and later pandemic (7% difference; 95% CI, –3% to 16%). In subgroup analyses, the early pandemic was associated with a larger impact in BTC resectability rates than HCC resectability rates. Time from BTC symptom onset until Multidisciplinary Liver Clinic evaluation increased by over 6 weeks early pandemic versus pre-pandemic (Hazard Ratio, 0.63; 95% CI, 0.44–0.91).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>During the early COVID-19 pandemic, we observed a drop in the percentage of patients presenting with curable liver cancers. This may reflect delays in liver cancer diagnosis and contribute to excess mortality related to the COVID-19 pandemic.</jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang