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Ungar, Andrea; Rivasi, Giulia; Di Bari, Mauro; Virdis, Agostino; Casiglia, Edoardo; Masi, Stefano; Mengozzi, Alessandro; Barbagallo, Carlo M.; Bombelli, Michele; Bruno, Bernardino; Cicero, Arrigo F.G.; Cirillo, Massimo; Cirillo, Pietro; Desideri, Giovambattista; D’elia, Lanfranco; Ferri, Claudio; Galletti, Ferruccio; Gesualdo, Loreto; Giannattasio, Cristina; Iaccarino, Guido; Ciccarelli, Michele; Lippa, Luciano; Mallamaci, Francesca; Maloberti, Alessandro; [...]

The association of uric acid with mortality modifies at old age: data from the uric acid right for heart health (URRAH) study

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  • Medientyp: E-Artikel
  • Titel: The association of uric acid with mortality modifies at old age: data from the uric acid right for heart health (URRAH) study
  • Beteiligte: Ungar, Andrea; Rivasi, Giulia; Di Bari, Mauro; Virdis, Agostino; Casiglia, Edoardo; Masi, Stefano; Mengozzi, Alessandro; Barbagallo, Carlo M.; Bombelli, Michele; Bruno, Bernardino; Cicero, Arrigo F.G.; Cirillo, Massimo; Cirillo, Pietro; Desideri, Giovambattista; D’elia, Lanfranco; Ferri, Claudio; Galletti, Ferruccio; Gesualdo, Loreto; Giannattasio, Cristina; Iaccarino, Guido; Ciccarelli, Michele; Lippa, Luciano; Mallamaci, Francesca; Maloberti, Alessandro; [...]
  • Erschienen: Ovid Technologies (Wolters Kluwer Health), 2022
  • Erschienen in: Journal of Hypertension
  • Sprache: Englisch
  • DOI: 10.1097/hjh.0000000000003068
  • ISSN: 1473-5598; 0263-6352
  • Schlagwörter: Cardiology and Cardiovascular Medicine ; Physiology ; Internal Medicine
  • Entstehung:
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  • Beschreibung: <jats:sec> <jats:title>Objectives:</jats:title> <jats:p>In older individuals, the role of serum uric acid (SUA) as risk factor for mortality is debated. This study investigated the association of SUA with all-cause and cardiovascular (CV) mortality in older adults participating in the large multicentre observational uric acid right for heart health (URRAH) study.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>Eight thousand URRAH participants aged 65+ were included in the analysis. The predictive role of SUA was assessed using Cox regression models stratified according to the cut-off age of 75. SUA was tested as continuous and categorical variable (age-specific quartiles). The prognostic threshold of SUA for mortality was analysed using receiver operating characteristic curves.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Among participants aged 65–74, multivariate Cox regression analysis adjusted for CV risk factors and comorbidities identified an independent association of SUA with both all-cause mortality (hazard ratio [HR] 1.169, 95% confidence interval [CI] 1.107–1.235) and CV mortality (HR 1.146, 95% CI 1.064–1.235). The cut-off value of 4.8 mg/dl discriminated mortality status. In participants aged 75+, we observed a J-shaped relationship of SUA with all-cause and CV mortality, with risk increasing at extreme SUA levels.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>These results confirmed the predictive role of SUA for all-cause and CV mortality in older adults, while revealing considerable age-related differences. Mortality risk increased at higher SUA levels in participants aged 65–74, with a prognostic threshold of 4.8 mg/dl. The relationship between SUA and mortality was J-shaped in oldest participants. Large interventional studies are needed to clarify the benefits and possible risks of urate-lowering treatments in older adults.</jats:p> </jats:sec>