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Tulling, Adam J.; Lugthart, Gertjan; Mooij, Miriam G.; Brackel, Caroline L. H.; Terheggen-Lagro, Suzanne W. J.; Oostenbrink, Rianne; Buysse, Corinne M. P.; Hashimoto, Simone; Armbrust, Wineke; Bannier, Michiel A. G. E.; Bekhof, Jolita; van Gameren-Oosterom, Helma B.; Hendriks, Han; van Houten, Marlies A.; van der Linden, Jan W.; Lebon, Ankie; van Onzenoort-Bokken, Lonneke; Tramper-Stranders, Gerdien A.; van Veen, Mirjam; von Asmuth, Erik G. J.; Buddingh, Emilie P.

Severe Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children From Wild-type to Population Immunity: A Prospective Multicenter Cohort Study With Real-time Reporting

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  • Medientyp: E-Artikel
  • Titel: Severe Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children From Wild-type to Population Immunity: A Prospective Multicenter Cohort Study With Real-time Reporting
  • Beteiligte: Tulling, Adam J.; Lugthart, Gertjan; Mooij, Miriam G.; Brackel, Caroline L. H.; Terheggen-Lagro, Suzanne W. J.; Oostenbrink, Rianne; Buysse, Corinne M. P.; Hashimoto, Simone; Armbrust, Wineke; Bannier, Michiel A. G. E.; Bekhof, Jolita; van Gameren-Oosterom, Helma B.; Hendriks, Han; van Houten, Marlies A.; van der Linden, Jan W.; Lebon, Ankie; van Onzenoort-Bokken, Lonneke; Tramper-Stranders, Gerdien A.; van Veen, Mirjam; von Asmuth, Erik G. J.; Buddingh, Emilie P.
  • Erschienen: Ovid Technologies (Wolters Kluwer Health), 2023
  • Erschienen in: Pediatric Infectious Disease Journal
  • Sprache: Englisch
  • DOI: 10.1097/inf.0000000000004098
  • ISSN: 0891-3668
  • Schlagwörter: Infectious Diseases ; Microbiology (medical) ; Pediatrics, Perinatology and Child Health
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  • Anmerkungen:
  • Beschreibung: <jats:sec> <jats:title>Background:</jats:title> <jats:p>SARS-CoV-2 variant evolution and increasing immunity altered the impact of pediatric SARS-CoV-2 infection. Public health decision-making relies on accurate and timely reporting of clinical data.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>This international hospital-based multicenter, prospective cohort study with real-time reporting was active from March 2020 to December 2022. We evaluated longitudinal incident rates and risk factors for disease severity.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>We included 564 hospitalized children with acute COVID-19 (n = 375) or multisystem inflammatory syndrome in children (n = 189) from the Netherlands, Curaçao and Surinam. In COVID-19, 134/375 patients (36%) needed supplemental oxygen therapy and 35 (9.3%) required intensive care treatment. Age above 12 years and preexisting pulmonary conditions were predictors for severe COVID-19. During omicron, hospitalized children had milder disease. During population immunity, the incidence rate of pediatric COVID-19 infection declined for older children but was stable for children below 1 year. The incidence rate of multisystem inflammatory syndrome in children was highest during the delta wave and has decreased rapidly since omicron emerged. Real-time reporting of our data impacted national pediatric SARS-CoV-2 vaccination- and booster-policies.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>Our data supports the notion that similar to adults, prior immunity protects against severe sequelae of SARS-CoV-2 infections in children. Real-time reporting of accurate and high-quality data is feasible and impacts clinical and public health decision-making. The reporting framework of our consortium is readily accessible for future SARS-CoV-2 waves and other emerging infections.</jats:p> </jats:sec>