Macías, Nicolás;
Sayagués, José M.;
Esteban, Carmen;
Iglesias, Manuel;
González, Luís M.;
Quiñones-Sampedro, Jose;
Gutiérrez, María L.;
Corchete, Luís A.;
Abad, Maria M.;
Bengoechea, Oscar;
Muñoz-Bellvis, Luís
Histologic Tumor Grade and Preoperative Bilary Drainage are the Unique Independent Prognostic Factors of Survival in Pancreatic Ductal Adenocarcinoma Patients After Pancreaticoduodenectomy
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Medientyp:
E-Artikel
Titel:
Histologic Tumor Grade and Preoperative Bilary Drainage are the Unique Independent Prognostic Factors of Survival in Pancreatic Ductal Adenocarcinoma Patients After Pancreaticoduodenectomy
Beteiligte:
Macías, Nicolás;
Sayagués, José M.;
Esteban, Carmen;
Iglesias, Manuel;
González, Luís M.;
Quiñones-Sampedro, Jose;
Gutiérrez, María L.;
Corchete, Luís A.;
Abad, Maria M.;
Bengoechea, Oscar;
Muñoz-Bellvis, Luís
Beschreibung:
<jats:sec>
<jats:title>Background and Aim:</jats:title>
<jats:p>Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer; most patients die during the first 6 months after diagnosis. With a 5% 5-year survival rate, is the fourth leading cause of cancer death in developed countries. In this regard, several clinical, histopathologic and biological characteristics of the disease favoring long-term survival after pancreaticoduodenectomy have been reported to be significant prognostic factors. Despite the availability of this information, there is no consensus about the different prognostic factors reported in the literature, probably due to variations in patient selection, methods, and sample size studied. The aim of this study was to identify the clinical and pathologic features associated to prognosis of the disease after pancreaticoduodenectomy.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Materials and Methods:</jats:title>
<jats:p>The clinical and pathologic data from 78 patients who underwent a potentially curative resection for PDAC at our institution between 2003 and 2014 were analyzed retrospectively.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Results:</jats:title>
<jats:p>Overall, high-grade PDAC cases showed larger tumor size (<jats:italic toggle="yes">P</jats:italic>=0.009) and a higher frequency of deaths in association with a nonsignificantly shortened patient overall survival (median of 12.5 vs. 21.7 mo; <jats:italic toggle="yes">P</jats:italic>=0.065) as compared with low-grade PDAC patients. High histologic grade (<jats:italic toggle="yes">P</jats:italic>=0.013), preoperative drainage on the main bile duct (<jats:italic toggle="yes">P</jats:italic>=0.014) and absence of adjuvant therapy (<jats:italic toggle="yes">P</jats:italic>=0.035) were associated with a significantly poorer outcome. Overall survival multivariate analysis showed histologic grade (<jats:italic toggle="yes">P</jats:italic>=0.019) and bile duct preoperative drainage (<jats:italic toggle="yes">P</jats:italic>=0.016) as the sole independent variables predicting an adverse outcome.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions:</jats:title>
<jats:p>Our results indicate that histologic tumor grade and preoperative biliary drainage are the only significant independent prognostic factors in PDAC patients after pancreatectomy.</jats:p>
</jats:sec>