Toomasian, John M.;
Jeakle, Mark M.P.;
Langley, Mark W.;
Poling, Clinton J.;
Lautner, Gergely;
Lautner-Csorba, Orsolya;
Meyerhoff, Mark M.;
Carr, Ben jamin D.;
Rojas-Pena, Alvaro;
Haft, Jonathan W.;
Bartlett, Robert H.
Nitric Oxide Attenuates the Inflammatory Effects of Air During Extracorporeal Circulation
Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Nitric Oxide Attenuates the Inflammatory Effects of Air During Extracorporeal Circulation
Beteiligte:
Toomasian, John M.;
Jeakle, Mark M.P.;
Langley, Mark W.;
Poling, Clinton J.;
Lautner, Gergely;
Lautner-Csorba, Orsolya;
Meyerhoff, Mark M.;
Carr, Ben jamin D.;
Rojas-Pena, Alvaro;
Haft, Jonathan W.;
Bartlett, Robert H.
Beschreibung:
<jats:p>Cardiopulmonary bypass causes a systemic inflammatory response reaction that may contribute to postoperative complications. One cause relates to the air/blood interface from the extracorporeal circuit. The modulatory effects of blending nitric oxide (NO) gas into the ventilation/sweep gas of the membrane lung was studied in a porcine model of air-induced inflammation in which NO gas was added and compared with controls with or without an air/blood interface. Healthy swine were supported on partial bypass under four different test conditions. Group 1: no air exposure, group 2: air alone, group 3: air plus 50 ppm NO, and group 4: air plus 500 ppm NO. The NO gas was blended into the ventilation/sweep site of the membrane lung. The platelets and leucocytes were activated by air alone. Addition of NO to the sweep gas attenuated the inflammatory response created by the air/blood interface in this model.</jats:p>