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Rajalahti, Teemu; Repo, Marleena; Kivelä, Laura; Huhtala, Heini; Mäki, Markku; Kaukinen, Katri; Lindfors, Katri; Kurppa, Kalle

Anemia in Pediatric Celiac Disease : Association With Clinical and Histological Features and Response to Gluten‐free Diet

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  • Medientyp: E-Artikel
  • Titel: Anemia in Pediatric Celiac Disease : Association With Clinical and Histological Features and Response to Gluten‐free Diet : Association With Clinical and Histological Features and Response to Gluten‐free Diet
  • Beteiligte: Rajalahti, Teemu; Repo, Marleena; Kivelä, Laura; Huhtala, Heini; Mäki, Markku; Kaukinen, Katri; Lindfors, Katri; Kurppa, Kalle
  • Erschienen: Wiley, 2017
  • Erschienen in: Journal of Pediatric Gastroenterology and Nutrition
  • Sprache: Englisch
  • DOI: 10.1097/mpg.0000000000001221
  • ISSN: 0277-2116; 1536-4801
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Goals:</jats:title><jats:p>The aim of the present study was to compare clinical, serological, and histological manifestations between children with anemia and without anemia at celiac disease (CD) diagnosis.</jats:p></jats:sec><jats:sec><jats:title>Background:</jats:title><jats:p>Despite being a common finding, the association between the presence of anemia and clinicohistopathological presentation of CD in children remains obscure.</jats:p></jats:sec><jats:sec><jats:title>Study:</jats:title><jats:p>A total of 455 patients with CD &lt;18 years of age were divided into those with anemia and those without anemia at diagnosis. The groups underwent comparisons of a variety of clinical, serological, and laboratory parameters and severity of small‐bowel mucosal damage. Furthermore, adherence and clinical and serological response to the gluten‐free diet (GFD) were compared.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>Anemia was detected in 18.0% of the patients. Children with anemia had higher values for transglutaminase 2 antibodies (120.0 U/L vs 88.0 U/L, <jats:italic>P</jats:italic> &lt; 0.001) and, by definition, lower values for hemoglobin (10.5 g/dL vs 12.8 g/dL, <jats:italic>P</jats:italic> &lt; 0.001) and other iron parameters. They were also less often screen‐detected (13.4% vs 34.6%), had more severe histological damage (<jats:italic>P</jats:italic> = 0.048), and poorer dietary adherence (78.3% vs 87.5%, <jats:italic>P</jats:italic> = 0.035) than the patients without anemia. A total of 92% of the patients recovered from anemia after a median of 1 year on a GFD, but hemoglobin values remained significantly lower compared with the nonanemic group (12.5 g/dL vs 13.2 g/dL, <jats:italic>P</jats:italic> = 0.045). There was no difference between the groups in the clinical and serological response to the GFD (<jats:italic>P</jats:italic> = 0.318).</jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p>Anemia at CD diagnosis is associated with more severe histological and serological presentation in children. Furthermore, low hemoglobin may not fully recover even after a median of 1 year on a strict GFD.</jats:p></jats:sec>
  • Zugangsstatus: Freier Zugang