• Medientyp: E-Artikel
  • Titel: Noncancer-related Secondary Findings in a Cohort of 231 Children With Cancer and Their Parents
  • Beteiligte: Wagener, Rabea; Walter, Carolin; Surowy, Harald M.; Brandes, Danielle; Soura, Stavrieta; Alzoubi, Deya; Yasin, Layal; Fischer, Ute; Dugas, Martin; Borkhardt, Arndt; Brozou, Triantafyllia
  • Erschienen: Ovid Technologies (Wolters Kluwer Health), 2023
  • Erschienen in: Journal of Pediatric Hematology/Oncology
  • Sprache: Englisch
  • DOI: 10.1097/mph.0000000000002475
  • ISSN: 1077-4114
  • Schlagwörter: Oncology ; Hematology ; Pediatrics, Perinatology and Child Health
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  • Beschreibung: <jats:p>Application of next-generation sequencing may lead to the detection of secondary findings (SF) not related to the initially analyzed disease but to other severe medically actionable diseases. However, the analysis of SFs is not yet routinely performed. We mined whole-exome sequencing data of 231 pediatric cancer patients and their parents who had been treated in our center for the presence of SFs. By this approach, we identified in 6 children (2.6%) pathogenic germline variants in 5 of the noncancer-related genes on the American College of Medical Genetics and Genomics (ACMG) SF v3.0 list, of which the majority were related to cardiovascular diseases (<jats:italic toggle="yes">RYR2</jats:italic>, <jats:italic toggle="yes">MYBPC3</jats:italic>, <jats:italic toggle="yes">KCNQ1</jats:italic>). Interestingly, only the patient harboring the <jats:italic toggle="yes">KCNQ1</jats:italic> variant showed at the time point of the analysis signs of the related Long QT syndrome. Moreover, we report 3 variants of unknown significance which, although not classified as pathogenic, have been reported in the literature to occur in individuals with the respective disease. While the frequency of patients with SFs is low, the impact of such findings on the patients’ life is enormous, with regard to the potential prevention of life-threatening diseases. Hence, we are convinced that such actionable SF should be routinely analyzed.</jats:p>