> Detailanzeige

Hudert, Christian A.; Tzschätzsch, Heiko; Rudolph, Birgit; Bläker, Hendrik; Loddenkemper, Christoph; Müller, Hans-Peter; Henning, Stephan; Bufler, Philip; Hamm, Bernd; Braun, Jürgen; Holzhütter, Hermann-Georg; Wiegand, Susanna; Sack, Ingolf; Guo, Jing

Tomoelastography for the Evaluation of Pediatric Nonalcoholic Fatty Liver Disease

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Tomoelastography for the Evaluation of Pediatric Nonalcoholic Fatty Liver Disease
  • Beteiligte: Hudert, Christian A.; Tzschätzsch, Heiko; Rudolph, Birgit; Bläker, Hendrik; Loddenkemper, Christoph; Müller, Hans-Peter; Henning, Stephan; Bufler, Philip; Hamm, Bernd; Braun, Jürgen; Holzhütter, Hermann-Georg; Wiegand, Susanna; Sack, Ingolf; Guo, Jing
  • Erschienen: Ovid Technologies (Wolters Kluwer Health), 2019
  • Erschienen in: Investigative Radiology
  • Sprache: Englisch
  • DOI: 10.1097/rli.0000000000000529
  • ISSN: 1536-0210; 0020-9996
  • Schlagwörter: Radiology, Nuclear Medicine and imaging ; General Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec> <jats:title>Objectives</jats:title> <jats:p>Today, nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and adults alike. Yet, the noninvasive evaluation of disease severity remains a diagnostic challenge. In this study, we apply multifrequency magnetic resonance elastography (mMRE) for the quantification of liver steatosis and fibrosis in adolescents with NAFLD.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Fifty adolescents (age range, 10–17 years; mean BMI, 33.9 kg/m<jats:sup>2</jats:sup>; range, 21.4–42.1 kg/m<jats:sup>2</jats:sup>) with biopsy-proven NAFLD were included in this prospective study. Multifrequency magnetic resonance elastography was performed using external multifrequency vibrations of 30 to 60 Hz and tomoelastography postprocessing, resulting in penetration rate (<jats:italic toggle="yes">a</jats:italic>) and shear wave speed (<jats:italic toggle="yes">c</jats:italic>). Hepatic fat fraction was determined using Dixon method. The diagnostic accuracy of mMRE in grading liver steatosis and staging liver fibrosis was assessed by receiver operating characteristic curve analysis.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Multifrequency magnetic resonance elastography parameters <jats:italic toggle="yes">c</jats:italic> and <jats:italic toggle="yes">a</jats:italic> were independently sensitive to fibrosis and steatosis, respectively, providing area under the receiver operating characteristic values of 0.79 (95% confidence interval [CI], 0.66–0.92), 0.91 (95% CI, 0.83–0.99), and 0.90 (95% CI, 0.80–0.99) for the detection of any (≥F1), moderate (≥F2), and advanced (≥F3) fibrosis, and 0.87 (95% CI, 0.76–0.97) and 0.87 (95% CI, 0.77–0.96) for the detection of moderate (≥S2) and severe (S3) steatosis.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>One mMRE measurement provides 2 independent parameters with very good diagnostic accuracy in detecting moderate and advanced fibrosis as well as moderate and severe steatosis in pediatric NAFLD.</jats:p> </jats:sec>