• Medientyp: E-Artikel
  • Titel: The Jezierski papers: live polio vaccine development in colobus monkey cells but not chimpanzee cells in the Belgian Congo, 1952–1958
  • Beteiligte: Desmyter, Jan; Teuwen, Dirk E.
  • Erschienen: The Royal Society, 2001
  • Erschienen in: Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 356 (2001) 1410, Seite 835-837
  • Sprache: Englisch
  • DOI: 10.1098/rstb.2001.0874
  • ISSN: 1471-2970; 0962-8436
  • Schlagwörter: General Agricultural and Biological Sciences ; General Biochemistry, Genetics and Molecular Biology
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  • Beschreibung: <jats:p>A reading of ten relevant papers by Alexandre Jezierski provides evidence for the only attempt in Central Africa to develop a live oral polio vaccine (OPV) from growing reference wild polio strains to 210 passages in colobus monkey tissue culture, and experimental administration to about 25 humans. Chimpanzees were used as a human model, but their tissues or kidneys were absent from the passage and production line of the proposed vaccine. Thus, the implication published by Hooper that Jezierski had produced a candidate OPV that might have contained chimpanzee viruses, possibly simian immunodeficiency virus cpz or the precursor of human immunodeficiency virus-1 group M, is incorrect.</jats:p>
  • Zugangsstatus: Freier Zugang