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Medientyp:
E-Artikel
Titel:
New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation
Beteiligte:
McLysaght, Aoife;
Guerzoni, Daniele
Erschienen:
The Royal Society, 2015
Erschienen in:
Philosophical Transactions of the Royal Society B: Biological Sciences, 370 (2015) 1678, Seite 20140332
Sprache:
Englisch
DOI:
10.1098/rstb.2014.0332
ISSN:
0962-8436;
1471-2970
Entstehung:
Anmerkungen:
Beschreibung:
The origin of novel protein-coding genes de novo was once considered so improbable as to be impossible. In less than a decade, and especially in the last five years, this view has been overturned by extensive evidence from diverse eukaryotic lineages. There is now evidence that this mechanism has contributed a significant number of genes to genomes of organisms as diverse asSaccharomyces,Drosophila,Plasmodium,Arabidopisisand human. From simple beginnings, these genes have in some instances acquired complex structure, regulated expression and important functional roles. New genes are often thought of as dispensable late additions; however, some recent de novo genes in human can play a role in disease. Rather than an extremely rare occurrence, it is now evident that there is a relatively constant trickle of proto-genes released into the testing ground of natural selection. It is currently unknown whether de novo genes arise primarily through an ‘RNA-first’ or ‘ORF-first’ pathway. Either way, evolutionary tinkering with this pool of genetic potential may have been a significant player in the origins of lineage-specific traits and adaptations.