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Medientyp:
E-Artikel
Titel:
Alternative mammalian strategies leading towards gastrulation: losing polar trophoblast (Rauber's layer) or gaining an epiblast cavity
Beteiligte:
Pfeffer, Peter L.
Erschienen:
The Royal Society, 2022
Erschienen in:
Philosophical Transactions of the Royal Society B: Biological Sciences, 377 (2022) 1865
Sprache:
Englisch
DOI:
10.1098/rstb.2021.0254
ISSN:
0962-8436;
1471-2970
Entstehung:
Anmerkungen:
Beschreibung:
Using embryological data from 14 mammalian orders, the hypothesis is presented that in placental mammals, epiblast cavitation and polar trophoblast loss are alternative developmental solutions to shield the central epiblast from extraembryonic signalling. It is argued that such reciprocal signalling between the edge of the epiblast and the adjoining polar trophoblast or edge of the mural trophoblast or with the amniotic ectoderm is necessary for the induction of gastrulation. This article is part of the theme issue ‘Extraembryonic tissues: exploring concepts, definitions and functions across the animal kingdom’.