Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents

Medientyp: E-Artikel
Titel: Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents
Beteiligte: Sanderson, Haley; Gray, Kristen L.; Manuele, Alexander; Maguire, Finlay; Khan, Amjad; Liu, Chaoyue; Navanekere Rudrappa, Chandana; Nash, John H. E.; Robertson, James; Bessonov, Kyrylo; Oloni, Martins; Alcock, Brian P.; Raphenya, Amogelang R.; McAllister, Tim A.; Peacock, Sharon J.; Raven, Kathy E.; Gouliouris, Theodore; McArthur, Andrew G.; Brinkman, Fiona S. L.; Fink, Ryan C.; Zaheer, Rahat; Beiko, Robert G.
Erschienen: Microbiology Society, 2022
Erschienen in: Microbial Genomics
Sprache: Englisch
DOI: 10.1099/mgen.0.000880
ISSN: 2057-5858
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Beschreibung: <jats:p> <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.5535" xlink:type="simple">Enterococcus faecium</jats:ext-link> </jats:named-content> </jats:italic> is a ubiquitous opportunistic pathogen that is exhibiting increasing levels of antimicrobial resistance (AMR). Many of the genes that confer resistance and pathogenic functions are localized on mobile genetic elements (MGEs), which facilitate their transfer between lineages. Here, features including resistance determinants, virulence factors and MGEs were profiled in a set of 1273 <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.5535" xlink:type="simple">E. faecium</jats:ext-link> </jats:named-content> </jats:italic> genomes from two disparate geographic locations (in the UK and Canada) from a range of agricultural, clinical and associated habitats. Neither lineages of <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.5535" xlink:type="simple">E. faecium</jats:ext-link> </jats:named-content> </jats:italic>, type A and B, nor MGEs are constrained by geographic proximity, but our results show evidence of a strong association of many profiled genes and MGEs with habitat. Many features were associated with a group of clinical and municipal wastewater genomes that are likely forming a new human-associated ecotype within type A. The evolutionary dynamics of <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.5535" xlink:type="simple">E. faecium</jats:ext-link> </jats:named-content> </jats:italic> make it a highly versatile emerging pathogen, and its ability to acquire, transmit and lose features presents a high risk for the emergence of new pathogenic variants and novel resistance combinations. This study provides a workflow for MGE-centric surveillance of AMR in <jats:italic> <jats:named-content content-type="genus"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.5525" xlink:type="simple">Enterococcus</jats:ext-link> </jats:named-content> </jats:italic> that can be adapted to other pathogens.</jats:p>
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