Post–COVID-19 Conditions Among Children 90 Days After SARS-CoV-2 Infection

Medientyp: E-Artikel
Titel: Post–COVID-19 Conditions Among Children 90 Days After SARS-CoV-2 Infection
Beteiligte: Funk, Anna L.; Kuppermann, Nathan; Florin, Todd A.; Tancredi, Daniel J.; Xie, Jianling; Kim, Kelly; Finkelstein, Yaron; Neuman, Mark I.; Salvadori, Marina I.; Yock-Corrales, Adriana; Breslin, Kristen A.; Ambroggio, Lilliam; Chaudhari, Pradip P.; Bergmann, Kelly R.; Gardiner, Michael A.; Nebhrajani, Jasmine R.; Campos, Carmen; Ahmad, Fahd A.; Sartori, Laura F.; Navanandan, Nidhya; Kannikeswaran, Nirupama; Caperell, Kerry; Morris, Claudia R.; Mintegi, Santiago; [...]
Erschienen: American Medical Association (AMA), 2022
Erschienen in: JAMA Network Open
Sprache: Englisch
DOI: 10.1001/jamanetworkopen.2022.23253
ISSN: 2574-3805
Entstehung:
Anmerkungen:
Beschreibung: <jats:sec id="ab-zoi220659-4"><jats:title>Importance</jats:title><jats:p>Little is known about the risk factors for, and the risk of, developing post–COVID-19 conditions (PCCs) among children.</jats:p></jats:sec><jats:sec id="ab-zoi220659-5"><jats:title>Objectives</jats:title><jats:p>To estimate the proportion of SARS-CoV-2–positive children with PCCs 90 days after a positive test result, to compare this proportion with SARS-CoV-2–negative children, and to assess factors associated with PCCs.</jats:p></jats:sec><jats:sec id="ab-zoi220659-6"><jats:title>Design, Setting, and Participants</jats:title><jats:p>This prospective cohort study, conducted in 36 emergency departments (EDs) in 8 countries between March 7, 2020, and January 20, 2021, included 1884 SARS-CoV-2–positive children who completed 90-day follow-up; 1686 of these children were frequency matched by hospitalization status, country, and recruitment date with 1701 SARS-CoV-2–negative controls.</jats:p></jats:sec><jats:sec id="ab-zoi220659-7"><jats:title>Exposure</jats:title><jats:p>SARS-CoV-2 detected via nucleic acid testing.</jats:p></jats:sec><jats:sec id="ab-zoi220659-8"><jats:title>Main Outcomes and Measures</jats:title><jats:p>Post–COVID-19 conditions, defined as any persistent, new, or recurrent health problems reported in the 90-day follow-up survey.</jats:p></jats:sec><jats:sec id="ab-zoi220659-9"><jats:title>Results</jats:title><jats:p>Of 8642 enrolled children, 2368 (27.4%) were SARS-CoV-2 positive, among whom 2365 (99.9%) had index ED visit disposition data available; among the 1884 children (79.7%) who completed follow-up, the median age was 3 years (IQR, 0-10 years) and 994 (52.8%) were boys. A total of 110 SARS-CoV-2–positive children (5.8%; 95% CI, 4.8%-7.0%) reported PCCs, including 44 of 447 children (9.8%; 95% CI, 7.4%-13.0%) hospitalized during the acute illness and 66 of 1437 children (4.6%; 95% CI, 3.6%-5.8%) not hospitalized during the acute illness (difference, 5.3%; 95% CI, 2.5%-8.5%). Among SARS-CoV-2–positive children, the most common symptom was fatigue or weakness (21 [1.1%]). Characteristics associated with reporting at least 1 PCC at 90 days included being hospitalized 48 hours or more compared with no hospitalization (adjusted odds ratio [aOR], 2.67 [95% CI, 1.63-4.38]); having 4 or more symptoms reported at the index ED visit compared with 1 to 3 symptoms (4-6 symptoms: aOR, 2.35 [95% CI, 1.28-4.31]; ≥7 symptoms: aOR, 4.59 [95% CI, 2.50-8.44]); and being 14 years of age or older compared with younger than 1 year (aOR, 2.67 [95% CI, 1.43-4.99]). SARS-CoV-2–positive children were more likely to report PCCs at 90 days compared with those who tested negative, both among those who were not hospitalized (55 of 1295 [4.2%; 95% CI, 3.2%-5.5%] vs 35 of 1321 [2.7%; 95% CI, 1.9%-3.7%]; difference, 1.6% [95% CI, 0.2%-3.0%]) and those who were hospitalized (40 of 391 [10.2%; 95% CI, 7.4%-13.7%] vs 19 of 380 [5.0%; 95% CI, 3.0%-7.7%]; difference, 5.2% [95% CI, 1.5%-9.1%]). In addition, SARS-CoV-2 positivity was associated with reporting PCCs 90 days after the index ED visit (aOR, 1.63 [95% CI, 1.14-2.35]), specifically systemic health problems (eg, fatigue, weakness, fever; aOR, 2.44 [95% CI, 1.19-5.00]).</jats:p></jats:sec><jats:sec id="ab-zoi220659-10"><jats:title>Conclusions and Relevance</jats:title><jats:p>In this cohort study, SARS-CoV-2 infection was associated with reporting PCCs at 90 days in children. Guidance and follow-up are particularly necessary for hospitalized children who have numerous acute symptoms and are older.</jats:p></jats:sec>
Zugangsstatus: Freier Zugang

Nur in Feld suchen:

Zuletzt gesuchte Begriffe: