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Medientyp:
E-Artikel
Titel:
Searching for Practically Useful P‐Chirogenic Phosphine Ligands
Beteiligte:
Imamoto, Tsuneo
Erschienen:
Wiley, 2016
Erschienen in:The Chemical Record
Sprache:
Englisch
DOI:
10.1002/tcr.201600098
ISSN:
1527-8999;
1528-0691
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>In this account, the design, synthesis, and application of P‐chirogenic phosphine ligands that have been mainly carried out in our laboratory over the last three decades are described. Various enantiopure P‐chirogenic phosphine ligands have been efficiently prepared by using phosphine boranes as intermediates. Conformationally rigid and electron‐rich P‐chirogenic phosphine ligands possessing <jats:italic>C</jats:italic><jats:sub>2</jats:sub> symmetry as well as a bulky alkyl group and a small group at the phosphorus atoms exhibit excellent enantioselectivities and catalytic efficiency in a variety of transition‐metal‐catalyzed asymmetric reactions. Enantiopure 2,3‐bis(<jats:italic>tert</jats:italic>‐butylmethylphosphino)quinoxaline (QuinoxP*) is an air‐stable crystalline solid that shows superior enantioinduction ability in catalytic asymmetric syntheses. Mechanistic studies of Rh‐catalyzed asymmetric hydrogenation using structurally simple P‐chirogenic phosphine ligands, such as <jats:italic>t</jats:italic>Bu‐BisP*, are briefly described.
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