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Gehringer, Michelle M.; Govender, Sharlene; Shah, Mrinal; Downing, Timothy G.

An investigation of the role of vitamin E in the protection of mice against microcystin toxicity

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  • Medientyp: E-Artikel
  • Titel: An investigation of the role of vitamin E in the protection of mice against microcystin toxicity
  • Beteiligte: Gehringer, Michelle M.; Govender, Sharlene; Shah, Mrinal; Downing, Timothy G.
  • Erschienen: Wiley, 2003
  • Erschienen in: Environmental Toxicology, 18 (2003) 2, Seite 142-148
  • Sprache: Englisch
  • DOI: 10.1002/tox.10110
  • ISSN: 1520-4081; 1522-7278
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>The presence of cyanobacterial toxins in drinking and recreational waters represents a potential public health risk. Microcystin‐LR (MC‐LR) is a potent cyclic heptapeptide hepatotoxin produced by the blue‐green alga <jats:italic>Microcystis aeruginosa</jats:italic>. Chemoprotectant studies have indicated that membrane‐active antioxidants such as vitamin E may offer protection against microcystin toxicity. This study investigated the effect of vitamin E supplementation on microcystin toxicity in mouse liver. Groups of mice were fed vitamin E supplements (8.33 or 33.3 U/mouse/day) for 4 weeks, with intraperitoneal doses of MC‐LR extract (70% LD<jats:sub>50</jats:sub>) every 3 days from day 8. The potential benefits of vitamin E were evaluated based on lipid peroxidation, alanine transaminase (ALT), and glutathione S‐transferase (GST) levels. Vitamin E supplementation at 33.3 U/mouse/day offered some protection against lipid peroxidation induced by repeated exposure to MC‐LR extract and limited both the toxin‐induced increase in ALT leakage and decrease in GST activity. Vitamin E supplementation at 66.6 U/mouse/day significantly increased the time to death and reduced the increase in liver percentage body weight induced in mice given a lethal dose challenge of MC‐LR extract. Therefore, vitamin E, taken as a dietary supplement, may have a protective effect against chronic exposure to MC‐LR. © 2003 Wiley Periodicals, Inc. Environ Toxicol 18: 142–148, 2003.</jats:p>