Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Modification of the vinylogous aldol condensation – Another approach to the synthesis of C(15)‐alkylidene and benzylidene andrographolide derivatives
Beteiligte:
Huy, Ly Minh;
Dung, Huynh Ha Ngoc;
Hy, Nguyen Dinh;
Trang, Le Bao;
Kien, Duong Trung;
Nghiem, Tieu Uy;
Van Anh, Tran Thi;
Tuyen, Truong Ngoc
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>A two‐step protocol for the synthesis of 15‐alkylidene and benzylidene derivatives of 14‐deoxy‐11,12‐didehydroandrographolide, which was conducted through a dehydration reaction of andrographolide and a vinylogous aldol condensation between <jats:italic>α</jats:italic>,<jats:italic>β</jats:italic>‐unsaturated butenolide moiety and benzaldehyde derivatives has been developed. Combining with various experiments on new catalysts for these reactions: the dehydration of andrographolide by concentrated H<jats:sub>2</jats:sub>SO<jats:sub>4</jats:sub> and the vinylogous aldol reaction by K<jats:sub>2</jats:sub>CO<jats:sub>3</jats:sub> in MeOH or a mixture of CH<jats:sub>3</jats:sub>COOH/pyrrolidine in MeOH, this research has determined the optimized conditions for those catalysts and the new approach to this aldol‐like reaction. All compounds synthesized were characterized by the analysis of IR, NMR, HRMS spectra.</jats:p>