Spatial regulation of PI3K signaling during chemotaxis

Medientyp: E-Artikel
Titel: Spatial regulation of PI3K signaling during chemotaxis
Beteiligte: Iglesias, Pablo A.
Erschienen: Wiley, 2009
Erschienen in: WIREs Systems Biology and Medicine
Sprache: Englisch
DOI: 10.1002/wsbm.13
ISSN: 1939-5094; 1939-005X
Schlagwörter: Biochemistry, Genetics and Molecular Biology (miscellaneous) ; Medicine (miscellaneous)
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Beschreibung: <jats:title>Abstract</jats:title><jats:p>Phosphoinositide 3‐kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3′ OH position of the inositol ring of phosphoinositides on the inner leaf of the plasma membrane. Receptor‐mediated activation of the PI3K pathway plays a crucial role in numerous signaling pathways and regulates a number of critical cellular processes, including growth, differentiation, survival and directed migration. In this focus article, we review the temporal and spatial regulation of PI3K in chemotaxing cells with particular emphasis on the amoeba <jats:italic>Dictyostelium</jats:italic> as well as neutrophils. We also briefly discuss one model used to elucidate the PI3K pathway. Copyright © 2009 John Wiley & Sons, Inc.</jats:p><jats:p>This article is categorized under: <jats:list list-type="explicit-label"> <jats:list-item><jats:p>Models of Systems Properties and Processes > Mechanistic Models</jats:p></jats:list-item> </jats:list></jats:p>

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