Metal and Substituent Influence on the Cytostatic Activity of Cationic Bis‐cyclometallated Iridium and Rhodium Complexes with Substituted 1,10‐Phenanthrolines as Ancillary Ligands
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Titel:
Metal and Substituent Influence on the Cytostatic Activity of Cationic Bis‐cyclometallated Iridium and Rhodium Complexes with Substituted 1,10‐Phenanthrolines as Ancillary Ligands
Beschreibung:
<jats:p>Synthesis and characterization of the new cyclometalated complex salts [Rh(ptpy)<jats:sub>2</jats:sub>(5.6‐dimethyl‐1,10‐phenanthroline)]PF<jats:sub>6</jats:sub> (<jats:bold>1a</jats:bold>) [Rh(ptpy)<jats:sub>2</jats:sub>(2.9‐dimethyl‐4.7‐diphenyl‐1,10‐ phenanthroline)]PF<jats:sub>6</jats:sub> (<jats:bold>2a</jats:bold>), [Rh(ptpy)<jats:sub>2</jats:sub>(5‐amino‐1,10‐phenanthroline)] PF<jats:sub>6</jats:sub> (<jats:bold>3a</jats:bold>), and [M(ptpy)<jats:sub>2</jats:sub> (pyrazino‐[2.3‐f]‐1,10‐phenanthroline)]PF<jats:sub>6</jats:sub> (M = Rh, <jats:bold>4a</jats:bold>; M = Ir, <jats:bold>4b</jats:bold>), (ptpy = 2‐(p‐tolyl)pyridinato) are described. The molecular structures of compounds <jats:bold>1b</jats:bold> and <jats:bold>4a</jats:bold> in the solid state were determined by single‐crystal X‐ray diffraction. All these compounds and their already known Iridium counterparts <jats:bold>1b</jats:bold> – <jats:bold>3b</jats:bold> display significant cytotoxicity against human cancer cell lines MCF‐7 (human breast adenocarcinoma) and HT‐29 (colon adenocarcinoma) with IC<jats:sub>50</jats:sub> values in the low micromolar range.</jats:p>