Erschienen in:
Journal of Applied Clinical Medical Physics, 24 (2023) 8
Sprache:
Englisch
DOI:
10.1002/acm2.14077
ISSN:
1526-9914
Entstehung:
Anmerkungen:
Beschreibung:
AbstractIntroductionPerforming lymphoscintigraphy in a separate room, frees up the conventional gamma camera, coupled with the desire to directly localize sentinel lymph nodes (SLN) in the operating theatre has led to the development of high‐resolution semiconductor‐detector based handheld gamma‐cameras, CrystalCam.MethodsThis work consists of phantom and clinical studies. For the first part, a Jaszczak phantom with hollow spheres of various volumes were filled with the 99mTc and the camera's sensitivity was measured at various distances to assess the possibilities and limitations of the device. The clinical study evaluates the effectiveness of CrystalCam in localizing SLN in 40 consecutive malignant melanoma patients compared to both conventional planar lymphoscintigraphy and hybrid SPECT/CT. SLNs detected by planar lymphoscintigraphy were marked on the patients’ skin using a UV‐marker. CrystalCam images were acquired in another room by another examiner and the SLNs were marked with a felt pen. The detected nodes by both camera systems were evaluated using UV‐lamp and normal light to visualize the UV‐ and felt pen marks respectively. The concordance rate of the SLNs and higher‐echelon nodes localized by both planar scintigraphy and CrystalCam imaging with respect to the total SLNs and higher‐echelon nodes detected by SPECT/CT imaging are compared and statistically analyzed.ResultsThe results of the phantom study show a good correlation between activity and count‐rates for all distancesSPECT/CT, CrystalCamm, and planar lymphoscintigraphy detected 69, 58, and 61 SLNs respectively. The concordance rate of 95.65% by the CrystalCam and planar scintigraphy implies both cameras are statistically coequal in preoperative SLN detection of malignant melanoma. For the higher‐echelon nodes, SPECT/CT, planar and CrystalCam imaging systems identified 82, 48, and 13 respectively; thus, CrystalCam was statistically inferior to planar imaging.ConclusionThe handheld CrystalCam is a reliable instrument for localizing SLNs in surgical centers without an on‐site nuclear medicine department.