Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Terminal complement activation is increased and associated with disease severity in CIDP
Beteiligte:
Quast, Isaak;
Keller, Christian W.;
Hiepe, Falk;
Tackenberg, Björn;
Lünemann, Jan D.
Erschienen:
Wiley, 2016
Erschienen in:
Annals of Clinical and Translational Neurology, 3 (2016) 9, Seite 730-735
Sprache:
Englisch
DOI:
10.1002/acn3.331
ISSN:
2328-9503
Entstehung:
Anmerkungen:
Beschreibung:
AbstractChronic inflammatory demyelinating polyneuropathy (CIDP) is the most common chronic autoimmune neuropathy. While both cell‐mediated and humoral mechanisms contribute to its pathogenesis, the rapid clinical response to plasmapheresis implicates a circulating factor responsible for peripheral nerve injury. We report that treatment‐naïve patients with CIDP show increased serum and CSF levels of the anaphylatoxin C5a and the soluble terminal complement complex (sTCC). Systemic terminal complement activation correlates with clinical disease severity as determined by the Inflammatory Neuropathy Cause and Treatment (INCAT) disability scale. These data indicate that complement activation contributes to peripheral nerve injury and suggest that complement inhibition should be explored for its potential therapeutic merit in CIDP.