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Medientyp:
E-Artikel
Titel:
Terminal complement activation is increased and associated with disease severity in CIDP
Beteiligte:
Quast, Isaak;
Keller, Christian W.;
Hiepe, Falk;
Tackenberg, Björn;
Lünemann, Jan D.
Erschienen:
Wiley, 2016
Erschienen in:Annals of Clinical and Translational Neurology
Sprache:
Englisch
DOI:
10.1002/acn3.331
ISSN:
2328-9503
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Chronic inflammatory demyelinating polyneuropathy (<jats:styled-content style="fixed-case">CIDP</jats:styled-content>) is the most common chronic autoimmune neuropathy. While both cell‐mediated and humoral mechanisms contribute to its pathogenesis, the rapid clinical response to plasmapheresis implicates a circulating factor responsible for peripheral nerve injury. We report that treatment‐naïve patients with <jats:styled-content style="fixed-case">CIDP</jats:styled-content> show increased serum and <jats:styled-content style="fixed-case">CSF</jats:styled-content> levels of the anaphylatoxin C5a and the soluble terminal complement complex (<jats:styled-content style="fixed-case">sTCC</jats:styled-content>). Systemic terminal complement activation correlates with clinical disease severity as determined by the Inflammatory Neuropathy Cause and Treatment (<jats:styled-content style="fixed-case">INCAT</jats:styled-content>) disability scale. These data indicate that complement activation contributes to peripheral nerve injury and suggest that complement inhibition should be explored for its potential therapeutic merit in <jats:styled-content style="fixed-case">CIDP</jats:styled-content>.</jats:p>