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Medientyp:
E-Artikel
Titel:
Double‐ to Single‐Strand Transition Induces Forces and Motion in DNA Origami Nanostructures
Beteiligte:
Gür, Fatih N.;
Kempter, Susanne;
Schueder, Florian;
Sikeler, Christoph;
Urban, Maximilian J.;
Jungmann, Ralf;
Nickels, Philipp C.;
Liedl, Tim
Erschienen:
Wiley, 2021
Erschienen in:Advanced Materials
Sprache:
Englisch
DOI:
10.1002/adma.202101986
ISSN:
0935-9648;
1521-4095
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>The design of dynamic, reconfigurable devices is crucial for the bottom‐up construction of artificial biological systems. DNA can be used as an engineering material for the de‐novo design of such dynamic devices. A self‐assembled DNA origami switch is presented that uses the transition from double‐ to single‐stranded DNA and vice versa to create and annihilate an entropic force that drives a reversible conformational change inside the switch. It is distinctively demonstrated that a DNA single‐strand that is extended with 0.34 nm per nucleotide – the extension this very strand has in the double‐stranded configuration – exerts a contractive force on its ends leading to large‐scale motion. The operation of this type of switch is demonstrated via transmission electron microscopy, DNA‐PAINT super‐resolution microscopy and darkfield microscopy. The work illustrates the intricate and sometimes counter‐intuitive forces that act in nanoscale physical systems that operate in fluids.</jats:p>