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Zbinden, Aline; Layland, Shannon L.; Urbanczyk, Max; Carvajal Berrio, Daniel A.; Marzi, Julia; Zauner, Monika; Hammerschmidt, Anne; Brauchle, Eva M.; Sudrow, Katrin; Fink, Simon; Templin, Markus; Liebscher, Simone; Klein, Gerd; Deb, Arjun; Duffy, Garry P.; Crooks, Gay M.; Eble, Johannes A.; Mikkola, Hanna K. A.; Nsair, Ali; Seifert, Martina; Schenke‐Layland, Katja

Nidogen‐1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration

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  • Medientyp: E-Artikel
  • Titel: Nidogen‐1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration
  • Beteiligte: Zbinden, Aline; Layland, Shannon L.; Urbanczyk, Max; Carvajal Berrio, Daniel A.; Marzi, Julia; Zauner, Monika; Hammerschmidt, Anne; Brauchle, Eva M.; Sudrow, Katrin; Fink, Simon; Templin, Markus; Liebscher, Simone; Klein, Gerd; Deb, Arjun; Duffy, Garry P.; Crooks, Gay M.; Eble, Johannes A.; Mikkola, Hanna K. A.; Nsair, Ali; Seifert, Martina; Schenke‐Layland, Katja
  • Erschienen: Wiley, 2021
  • Erschienen in: Advanced Science
  • Sprache: Englisch
  • DOI: 10.1002/advs.202002500
  • ISSN: 2198-3844
  • Schlagwörter: General Physics and Astronomy ; General Engineering ; Biochemistry, Genetics and Molecular Biology (miscellaneous) ; General Materials Science ; General Chemical Engineering ; Medicine (miscellaneous)
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Ischemia impacts multiple organ systems and is the major cause of morbidity and mortality in the developed world. Ischemia disrupts tissue homeostasis, driving cell death, and damages tissue structure integrity. Strategies to heal organs, like the infarcted heart, or to replace cells, as done in pancreatic islet <jats:italic>β</jats:italic>‐cell transplantations, are often hindered by ischemic conditions. Here, it is discovered that the basement membrane glycoprotein nidogen‐1 attenuates the apoptotic effect of hypoxia in cardiomyocytes and pancreatic <jats:italic>β</jats:italic>‐cells via the <jats:italic>α</jats:italic>v<jats:italic>β</jats:italic>3 integrin and beneficially modulates immune responses in vitro. It is shown that nidogen‐1 significantly increases heart function and angiogenesis, while reducing fibrosis, in a mouse postmyocardial infarction model. These results demonstrate the protective and regenerative potential of nidogen‐1 in ischemic conditions.</jats:p>
  • Zugangsstatus: Freier Zugang