Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23‐24.1

Medientyp: E-Artikel
Titel: Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23‐24.1
Beteiligte: Dawson, Elisabeth; Parfitt, Elizabeth; Roberts, Queta; Daniels, Jo; Lim, Lionel; Sham, Pak; Nöthen, Markus; Propping, Peter; Lanczik, Mario; Maier, Wolfgang; Reuner, Ulrike; Weissenbach, Jean; Gill, Michael; Powell, John; McGuffin, Peter; Owen, Mike; Craddock, Nick
Erschienen: Wiley, 1995
Erschienen in: American Journal of Medical Genetics
Sprache: Englisch
DOI: 10.1002/ajmg.1320600203
ISSN: 0148-7299; 1096-8628
Schlagwörter: Genetics (clinical)
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Beschreibung: <jats:title>Abstract</jats:title><jats:p>We have recently described a family in which there is cosegregation of major affective disorder with Darier's disease and have mapped this autosomal dominant skin disorder to 12q23‐q24.1. This has provided an interesting candidate region for genetic studies of bipolar disorder. We have studied the segregation of seven markers spanning the Darier's disease locus in 45 bipolar disorder pedigrees and found modest evidence in support of linkage under heterogeneity for 5 of these markers. Nonparametric analyses were suggestive of linkage with a marker at the gene encoding a secretory form of phospholipase A2. Our sample has relatively low power to detect linkage under heterogeneity and independent researchers should examine markers from this region in further samples of bipolar pedigrees. © 1995 Wiley‐Liss, Inc.</jats:p>

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