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Rodríguez‐Rodríguez, Eloy; Llorca, Javier; Mateo, Ignacio; Infante, Jon; Sánchez‐Quintana, Coro; García‐Gorostiaga, Inés; Fernández‐Viadero, Carlos; Peña, Nicolás; Berciano, José; Combarros, Onofre

No association of genetic variants of liver X receptor‐β with alzheimer's disease risk

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  • Medientyp: E-Artikel
  • Titel: No association of genetic variants of liver X receptor‐β with alzheimer's disease risk
  • Beteiligte: Rodríguez‐Rodríguez, Eloy; Llorca, Javier; Mateo, Ignacio; Infante, Jon; Sánchez‐Quintana, Coro; García‐Gorostiaga, Inés; Fernández‐Viadero, Carlos; Peña, Nicolás; Berciano, José; Combarros, Onofre
  • Erschienen: Wiley, 2008
  • Erschienen in: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
  • Sprache: Englisch
  • DOI: 10.1002/ajmg.b.30652
  • ISSN: 1552-4841; 1552-485X
  • Schlagwörter: Cellular and Molecular Neuroscience ; Psychiatry and Mental health ; Genetics (clinical)
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Apolipoprotein E (<jats:italic>APOE</jats:italic>) ε4 allele is the strongest hitherto known risk factor for sporadic Alzheimer's disease (AD). Liver X receptor‐β (LXRβ) is a transcription factor that controls expression of genes involved in brain cholesterol metabolism, and one of the main LXRβ targets is APOE. To evaluate the relationship between <jats:italic>LXRβ</jats:italic> genetic variants and AD, independently or in concert with the <jats:italic>APOE</jats:italic> ε4 allele, we examined three <jats:italic>LXRβ</jats:italic> polymorphisms located in introns 2 (rs 2695121), 5 (rs 1052533), and 7 (rs 1405655), in 414 Spanish AD patients and 447 controls. The current study does not demonstrate an association between <jats:italic>LXRβ</jats:italic> genotypes or haplotypes and AD, neither in the total sample nor when the populations were stratified for the presence or absence of the <jats:italic>APOE</jats:italic> ε4 allele. © 2007 Wiley‐Liss, Inc.</jats:p>