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Medientyp:
E-Artikel
Titel:
Occupational generalized urticaria and anaphylaxis after inhalation of cefuroxime in a nurse
Beteiligte:
Merget, Rolf;
Sander, Ingrid;
Fartasch, Manigé;
van Kampen, Vera;
Röseler, Stefani;
Merk, Hans;
Wurpts, Gerda;
Raulf, Monika;
Brüning, Thomas
Erschienen:
Wiley, 2018
Erschienen in:
American Journal of Industrial Medicine, 61 (2018) 3, Seite 261-266
Sprache:
Englisch
DOI:
10.1002/ajim.22788
ISSN:
0271-3586;
1097-0274
Entstehung:
Anmerkungen:
Beschreibung:
We present the case of a 53 years old nonatopic female nurse who experienced repeated anaphylactic reactions at work without involvement in drug‐specific tasks such as crushing of tablets or preparation of injections. The causal allergen was not identified until a further severe anaphylactic reaction occurred after oral use of cefuroxime during a respiratory infection. Sensitization to cefuroxime was demonstrated by specific IgE, basophil activation test and skin prick test. An inhalation challenge with a dosimeter induced generalized urticaria after a cumulative dose of about 10 μg of the drug, but no asthmatic reaction. Complete exposure cessation was initiated and a 1‐year follow‐up was without further allergic reactions. We conclude that work‐related systemic allergic reactions to β‐lactam antibiotics may occur in nurses after inhalation of low doses and without perceived association with drug‐specific tasks like handling of antibiotics.