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Medientyp:
E-Artikel
Titel:
Inbreeding, heterozygosity, and lymphoma risk among the baboons (Papio hamadryas) of Sukhumi, USSR
Beteiligte:
Crawford, Michael H.;
O'Rourke, Dennis H.;
Dykes, Dale D.;
Yakovleva, L. A.;
Voevodin, A. F.;
Lapin, Boris;
Polesky, H. F.
Erschienen:
Wiley, 1984
Erschienen in:
American Journal of Primatology, 6 (1984) 3, Seite 143-153
Sprache:
Englisch
DOI:
10.1002/ajp.1350060303
ISSN:
0275-2565;
1098-2345
Entstehung:
Anmerkungen:
Beschreibung:
AbstractThis paper describes the spread of lymphoma through a baboon (Papio hamadryas) colony in the Institute of Experimental Pathology and Therapy at Sukhumi, USSR. In the late 1960s, Soviet scientists inoculated 12 baboons with cells from hospitalized human leukemia patients, causing the death of a total of 135 animals between 1967 and 1978. The death rate from lymphoma averages almost 12 baboons per year in the Sukhumi colony. Genetic investigations of these baboons revealed the following: 1) Six blood protein markers out of 16 systems (38%) tested were polymorphic; 2) the average inbreeding coefficient for the entire colony (N = 1,226) was 0.027 (exclusion of baboons with F values equal to 0.0 raised the mean inbreeding coefficient to 0.096); 3) no relationship between inbreeding and risk of lymphoma was noted; and 4) there was an apparent association between both PGM loci and the incidence of lymphoma at the 0.005 levels of significance. This association was further supported by the significantly lower incidence of PGM2 (2‐1) genotype in baboons with high anti‐VCA‐HVP titers.