• Medientyp: E-Artikel
  • Titel: A Genetic Risk Variant for Multiple Sclerosis Severity is Associated with Brain Atrophy
  • Beteiligte: Gasperi, Christiane; Wiltgen, Tun; McGinnis, Julian; Cerri, Stefano; Moridi, Thomas; Ouellette, Russell; Pukaj, Albert; Voon, Cuici; Bafligil, Cemsel; Lauerer, Markus; Andlauer, Till F. M.; Held, Friederike; Aly, Lilian; Shchetynsky, Klementy; Stridh, Pernilla; Harroud, Adil; Wiestler, Benedikt; Kirschke, Jan S.; Zimmer, Claus; Baras, Aris; Piehl, Fredrik; Berthele, Achim; Granberg, Tobias; Kockum, Ingrid; [...]
  • Erschienen: Wiley, 2023
  • Erschienen in: Annals of Neurology
  • Sprache: Englisch
  • DOI: 10.1002/ana.26807
  • ISSN: 0364-5134; 1531-8249
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  • Beschreibung: <jats:p>The minor allele of the genetic variant rs10191329 in the <jats:italic>DYSF‐ZNF638</jats:italic> locus is associated with unfavorable long‐term clinical outcomes in multiple sclerosis patients. We investigated if rs10191329 is associated with brain atrophy measured by magnetic resonance imaging in a discovery cohort of 748 and a replication cohort of 360 people with relapsing multiple sclerosis. We observed an association with 28% more brain atrophy per rs10191329*A allele. Our results encourage stratification for rs10191329 in clinical trials. Unraveling the underlying mechanisms may enhance our understanding of pathophysiology and identify treatment targets. ANN NEUROL 2023;94:1080–1085</jats:p>