Kim, Heejin;
Kim, Sungwhan;
Kang, Sunyoung;
Song, Youngjun;
Shin, Suyong;
Lee, Seonju;
Kang, Minji;
Nam, So Hee;
Lee, Yan
Ring Opening Metathesis Polymerization of Bicyclic α,β‐Unsaturated Anhydrides for Ready‐to‐be‐grafted Polymers Having Tailored pH‐Responsive Degradability
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Medientyp:
E-Artikel
Titel:
Ring Opening Metathesis Polymerization of Bicyclic α,β‐Unsaturated Anhydrides for Ready‐to‐be‐grafted Polymers Having Tailored pH‐Responsive Degradability
Beteiligte:
Kim, Heejin;
Kim, Sungwhan;
Kang, Sunyoung;
Song, Youngjun;
Shin, Suyong;
Lee, Seonju;
Kang, Minji;
Nam, So Hee;
Lee, Yan
Erschienen:
Wiley, 2018
Erschienen in:
Angewandte Chemie, 130 (2018) 38, Seite 12648-12652
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Polymers having α,β‐unsaturated anhydrides as repeating units were synthesized by ring opening metathesis polymerization (ROMP). The anhydride moieties were ready‐to‐be‐grafted with amines to form acid‐labile cis‐α,β‐unsaturated acid amide linkages. The pH‐responsive reversible de‐grafting can be controlled by changing the intramolecular accessibility between acid and amide groups. The alendronate‐grafted ROMP polymers showed distinct pH‐dependent cytotoxicity according to the anhydride structures.</jats:p>