• Medientyp: E-Artikel
  • Titel: Visible‐Light‐Mediated Energy Transfer Enables the Synthesis of β‐Lactams via Intramolecular Hydrogen Atom Transfer
  • Beteiligte: Oddy, Meghan J.; Kusza, Daniel A.; Epton, Ryan G.; Lynam, Jason M.; Unsworth, William P.; Petersen, Wade F.
  • Erschienen: Wiley, 2022
  • Erschienen in: Angewandte Chemie International Edition, 61 (2022) 48
  • Sprache: Englisch
  • DOI: 10.1002/anie.202213086
  • ISSN: 1433-7851; 1521-3773
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  • Beschreibung: AbstractThe synthesis of 2‐azetidinones (β‐lactams) from simple acrylamide starting materials by visible‐light‐mediated energy transfer catalysis is reported. The reaction features a C(sp3)−H functionalization via a variation of the Norrish–Yang photocyclization involving a carbon‐to‐carbon 1,5‐hydrogen atom transfer (supported by deuterium labelling and DFT calculations) and can be used for the construction of a diverse range of β‐lactam products.