Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Synthesis of Heterocycles by Formal Cycloadditions of Isocyanides
Beteiligte:
Kruithof, Art;
Ruijter, Eelco;
Orru, Romano V. A.
Erschienen:
Wiley, 2015
Erschienen in:
Chemistry – An Asian Journal, 10 (2015) 3, Seite 508-520
Sprache:
Englisch
DOI:
10.1002/asia.201403207
ISSN:
1861-4728;
1861-471X
Entstehung:
Anmerkungen:
Beschreibung:
AbstractSynthetic methodology for the synthesis of heterocycles is of continuous and high interest with applications in materials, catalysis, and medicines. Multicomponent reactions are suitable tools to efficiently generate chemically diverse sets of heterocycles with sufficient structural complexity. Especially isocyanides have proven to be particularly versatile building blocks in these one‐pot processes. Due to their electronic structure, isocyanides are able to act sequentially or simultaneously as a nucleophile and an electrophile. Traditionally, isocyanides are therefore frequently used in multicomponent chemistry. In the recent literature, numerous reactions have been reported that involve formal cycloadditions of isocyanides with conjugated heterodienes. This Focus Review aims at mapping this reactivity and at providing insight into the relationship between the various reported reaction partners and the observed reactivity modes.