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Medientyp: E-Artikel Titel: Temperature sensitive semi‐IPN microspheres from sodium alginate and N‐isopropylacrylamide for controlled release of 5‐fluorouracil Beteiligte: Mallikarjuna Reddy, K.; Ramesh Babu, V.; Krishna Rao, K. S. V.; Subha, M. C. S.; Chowdoji Rao, K.; Sairam, M.; Aminabhavi, T. M. Erschienen: Wiley, 2008 Erschienen in: Journal of Applied Polymer Science, 107 (2008) 5, Seite 2820-2829 Sprache: Englisch DOI: 10.1002/app.27305 ISSN: 0021-8995; 1097-4628 Schlagwörter: Materials Chemistry ; Polymers and Plastics ; Surfaces, Coatings and Films ; General Chemistry Entstehung: Anmerkungen: Beschreibung: <jats:title>Abstract</jats:title><jats:p>Semi‐interpenetrating network (IPN) of sodium alginate (NaAlg) and <jats:italic>N</jats:italic>‐isopropylacrylamide (NIPAAm) microspheres were prepared by water‐in‐oil (w/o) emulsification method. The microspheres were encapsulated with 5‐fluorouracil (5‐FU) and release patterns carried in 7.4 pH at temperatures of 25 and 37°C. The semi‐IPN microspheres were characterized by Fourier transform infrared spectroscopy (FTIR). Differential scanning calorimetry (DSC) and scanning electron microscopic studies were done on the drug‐loaded microspheres to confirm the polymorphism of 5‐FU and surface morphology of microspheres. These results indicated the molecular level dispersion of 5‐FU in the semi‐IPN microspheres. Particle size and size distribution were studied by laser light diffraction technique. Microspheres exhibited release of 5‐FU up to 12 h. The swelling studies were carried in 1.2 and 7.4 pH buffer media at 25 and 37°C. Drug release from NaAlg‐NIPAAm semi‐IPN microspheres at 25 and 37°C confirmed the thermosensitive nature by <jats:italic>in vitro</jats:italic> dissolution. The micro domains have released in a controlled manner due the presence of NIPAAm in the matrix. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008</jats:p>