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Ćurčić, Vladimir; Olszewski, Mateusz; Maciejewska, Natalia; Višnjevac, Aleksandar; Srdić‐Rajić, Tatjana; Dobričić, Vladimir; García‐Sosa, Alfonso T.; Kokanov, Sanja B.; Araškov, Jovana B.; Silvestri, Romano; Schüle, Roland; Jung, Manfred; Nikolić, Milan; Filipović, Nenad R.

Quinoline‐based thiazolyl‐hydrazones target cancer cells through autophagy inhibition

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  • Medientyp: E-Artikel
  • Titel: Quinoline‐based thiazolyl‐hydrazones target cancer cells through autophagy inhibition
  • Beteiligte: Ćurčić, Vladimir; Olszewski, Mateusz; Maciejewska, Natalia; Višnjevac, Aleksandar; Srdić‐Rajić, Tatjana; Dobričić, Vladimir; García‐Sosa, Alfonso T.; Kokanov, Sanja B.; Araškov, Jovana B.; Silvestri, Romano; Schüle, Roland; Jung, Manfred; Nikolić, Milan; Filipović, Nenad R.
  • Erschienen: Wiley, 2024
  • Erschienen in: Archiv der Pharmazie
  • Sprache: Englisch
  • DOI: 10.1002/ardp.202300426
  • ISSN: 0365-6233; 1521-4184
  • Schlagwörter: Drug Discovery ; Pharmaceutical Science
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)‐approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl‐hydrazones based on the 8‐quinoline (<jats:bold>1a–c</jats:bold>), 2‐quinoline (<jats:bold>2a–c</jats:bold>), and 8‐hydroxy‐2‐quinolyl moiety (<jats:bold>3a–c</jats:bold>). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK‐293 were used to evaluate the compound‐mediated in vitro anticancer activities, leading to [2‐(2‐(quinolyl‐8‐ol‐2‐ylmethylene)hydrazinyl)]‐4‐(4‐methoxyphenyl)‐1,3‐thiazole (<jats:bold>3c</jats:bold>) as the most promising compound. The study revealed that <jats:bold>3c</jats:bold> blocks the cell‐cycle progression of a human colon cancer cell line (HCT‐116) in the S phase and induces DNA double‐strand breaks. Also, our findings demonstrate that <jats:bold>3c</jats:bold> accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep‐G2) and HCT‐116 cells, by the mechanism of autophagy inhibition.</jats:p>