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Medientyp: E-Artikel Titel: Improving TNF as a cancer therapeutic: Tailor‐made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects Beteiligte: Gerspach, Jeannette; Pfizenmaier, Klaus; Wajant, Harald Erschienen: Wiley, 2009 Erschienen in: BioFactors Sprache: Englisch DOI: 10.1002/biof.50 ISSN: 0951-6433; 1872-8081 Schlagwörter: Clinical Biochemistry ; Molecular Medicine ; General Medicine ; Biochemistry Entstehung: Anmerkungen: Beschreibung: <jats:title>Abstract</jats:title><jats:p>Tumor necrosis factor (TNF) is highly pleiotropic cytokine regulating diverse cellular processes such as proliferation, cell migration, angiogenesis, differentiation, apoptosis, necrosis, but also survival. Because of its name‐giving tumor necrosis‐inducing capabilities, TNF has attracted attention very early for antitumor therapy. Although TNF is in clinical use for treatment of soft tissue sarcoma in isolated limb perfusion, its broad use in tumor therapy is prevented so far by its strong systemic proinflammatory effects. Nevertheless, over the past decade, a variety of tailor‐made TNF variants have been developed with the aim to reduce TNFs systemic activity without losing its antitumoral effects. Here, we review the progress made toward improving the efficacy of TNF by genetic engineering, tumor targeting, and introduction of prodrug concepts. © 2009 International Union of Biochemistry and Molecular Biology, Inc.</jats:p>