Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Opening the genetic toolbox of niche model organisms with high throughput techniques: Novel proteins in regeneration as a case study
Beteiligte:
Looso, Mario
Erschienen:
Wiley, 2014
Erschienen in:
BioEssays, 36 (2014) 4, Seite 407-418
Sprache:
Englisch
DOI:
10.1002/bies.201300093
ISSN:
0265-9247;
1521-1878
Entstehung:
Anmerkungen:
Beschreibung:
AbstractUnderstanding in vivo regeneration of complex structures offers a fascinating perspective for translation into medical applications. Unfortunately, mammals in general lack large‐scale regenerative capacity, whereas planarians, newts or Hydra can regenerate complete body parts. Such organisms are, however, poorly annotated because of the lack of sequence information. This leads to limited access for molecular biological investigations. In the last decade, high throughput technologies and new methods enabling the effective generation of transgenic animals have rapidly evolved. These developments have allowed the extensive use of niche model organisms as part of a trend towards the accessibility of a greater panel of model species for scientific research. The case study that follows provides an insight into the impact of high throughput techniques on the landscape of models of regeneration. The cases presented here give evidence of alternative stem cell maintenance pathways, the identification of new protein families and new stem cell markers.