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Medientyp:
E-Artikel
Titel:
Assessment of biological activities of chitosan Schiff base tagged with medicinal plants
Beteiligte:
Khan, Arshad Mehmood;
Abid, Obaid ur Rehman;
Mir, Sadullah
Erschienen:
Wiley, 2020
Erschienen in:Biopolymers
Sprache:
Englisch
DOI:
10.1002/bip.23338
ISSN:
1097-0282;
0006-3525
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>A chitosan Schiff base with an aromatic aldehyde was synthesized and characterized by FTIR and NMR spectroscopies. Furthermore, the degree of substitution was calculated based on the ratios of the area of the proton of the imine (<jats:italic>A</jats:italic><jats:sub>imine</jats:sub>) and the area of the peak of the proton of the pyranose ring (<jats:italic>A</jats:italic><jats:sub>H‐2</jats:sub>). The antimicrobial activities were determined against bacterial and fungal strains, as well as multiple drug‐resistant (MDR) bacteria. The chitosan Schiff base was also tagged with medicinal plants, for example, <jats:italic>Curcuma longa</jats:italic>, <jats:italic>Peganum harmala</jats:italic>, <jats:italic>Lepidium sativam</jats:italic>, and cruciferous vegetables, and the biological activities determined against pathogenic bacterial and fungal strains. The chitosan Schiff base showed maximum zone of inhibition of 22 mm against <jats:italic>Staphylococcus aureus</jats:italic> with a minimum zone of inhibition of 15 mm against <jats:italic>Bacillus cereus</jats:italic>. The chitosan Schiff base was fused with <jats:italic>C longa</jats:italic>, isothiocyanates and a combined mixture of <jats:italic>P harmala</jats:italic> and <jats:italic>L sativam</jats:italic> that has shown activities against <jats:italic>Escherichia coli</jats:italic> with a zone of inhibition of 28, 24, and 30 mm, respectively. The Schiff base of chitosan fused with medicinal plants also showed significant inhibitory activities against MDR bacteria.</jats:p>