Beschreibung:
<jats:title>Abstract</jats:title><jats:p>The interactions of the ribonucleotide poly C with <jats:italic>cis</jats:italic>‐ and <jats:italic>trans</jats:italic>‐diamminedichloroplatinum (II) were probed with Raman spectroscopy. Both platinum compounds attack the <jats:italic>N</jats:italic>‐1 position of the cytosine residue, while the <jats:italic>trans</jats:italic> form appears to attack the PO<jats:sub>2</jats:sub><jats:sup>−</jats:sup> as well. Raman difference spectra obtained from samples of poly C containing similar amounts of the respective <jats:italic>Pt</jats:italic> compounds indicate that the <jats:italic>trans</jats:italic> form is able to disrupt the secondary structure of poly C to a greater degree than the <jats:italic>cis</jats:italic> form. This latter observation may be a contributing factor in the low therapeutic index exhibited by the <jats:italic>trans</jats:italic> form.</jats:p>