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Rothman, Martin T.; Jain, Ajay K.

Outcomes in patients with renal impairment undergoing percutaneous coronary intervention and implantation of the Endeavor zotarolimus‐eluting stent: 1‐ and 2‐year data from the E‐Five Registry

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  • Medientyp: E-Artikel
  • Titel: Outcomes in patients with renal impairment undergoing percutaneous coronary intervention and implantation of the Endeavor zotarolimus‐eluting stent: 1‐ and 2‐year data from the E‐Five Registry
  • Beteiligte: Rothman, Martin T.; Jain, Ajay K.
  • Erschienen: Wiley, 2012
  • Erschienen in: Catheterization and Cardiovascular Interventions, 80 (2012) 6, Seite 885-892
  • Sprache: Englisch
  • DOI: 10.1002/ccd.23484
  • ISSN: 1522-726X; 1522-1946
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: AbstractObjectivesRenal impairment (RI) is a predictor of poor outcomes in patients with cardiovascular disease, but its influence in the setting of percutaneous coronary intervention and zotarolimus‐eluting stent (ZES) implantation has not been described. This study evaluated the impact of RI on clinical outcomes in patients participating in the E‐Five Registry. Background: E‐Five was a prospective, multicenter, global registry of 8,314 patients; 2,116 patients were followed to 2 years.MethodsPatients (excluding those who had undergone renal transplantation) were grouped according to renal function (normal function/mild RI, serum creatinine <110 μmol/L; moderate RI, 110–200 μmol/L; severe RI, >200 μmol/L) and their outcomes evaluated retrospectively. Major adverse cardiac events (MACE; i.e., death, myocardial infarction, emergency cardiac bypass surgery, or target lesion revascularization) and stent thrombosis events at 1 and 2 years were compared between groups.ResultsThe 1‐year MACE rate in patients with mild RI was 6.8%, compared with 8.9 and 18.1% in patients with moderate and severe RI (P = 0.002 across groups). At 2 years, death occurred in 16% of those with severe RI, compared with 2.0 and 4.7% in those with mild and moderate RI (P = 0.002). There was no significant difference in the rates of target lesion revascularization or target vessel failure.ConclusionsGreater severity of RI at intervention is associated with greater mortality and MACE but unchanged revascularization rates after ZES implantation. © 2012 Wiley Periodicals, Inc.