Beschreibung:
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objectives</jats:title><jats:p>To assess the clinical characteristics, management, and outcomes of patients diagnosed with infective endocarditis (IE) after edge‐to‐edge mitral valve repair with the MitraClip device.</jats:p></jats:sec><jats:sec><jats:title>Background</jats:title><jats:p>Transcatheter edge‐to‐edge mitral valve repair has emerged as an alternative to surgery in high‐risk patients. However, few data exist on IE following transcatheter mitral procedures.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Four electronic databases (PubMed, Google Scholar, Embase, and Cochrane Library) were searched for original published studies on IE after edge‐to‐edge transcatheter mitral valve repair from 2003 to 2017.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 10 publications describing 12 patients with definitive IE (median age 76 years, 55% men) were found. The mean logistic EuroSCORE/EuroSCORE II were 41% and 45%, respectively. The IE episode occurred early (within 12 months post‐procedure) in nine patients (75%; within the first month in five patients). <jats:italic>Staphylococcus aureus</jats:italic> was the most frequent (60%) causal microorganism, and severe mitral regurgitation was present in all cases but one. Surgical mitral valve replacement (SMVR) was performed in most (67%) patients, and the mortality associated with the IE episode was high (42%).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>IE following transcatheter edge‐to‐edge mitral valve repair is a rare but life‐threatening complication, usually necessitating SMVR despite the high‐risk profile of the patients. These results highlight the importance of adequate preventive measures and a prompt diagnosis and treatment of this serious complication.</jats:p></jats:sec>