Beschreibung:
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Coronary artery disease (CAD) is a common finding in patients undergoing transcatheter aortic valve implantation (TAVI). However, its prognostic significance and its management remains controversial.</jats:p></jats:sec><jats:sec><jats:title>Aims</jats:title><jats:p>This study sought to determine whether the presence of CAD, its complexity, and angiography‐guided percutaneous coronary intervention (PCI) are associated with outcomes after TAVI.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>All patients undergoing TAVI at a tertiary referral center between 2008 and 2018 were included in a prospective observational study. Baseline SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) score (SS) and a residual SS after PCI were calculated. The endpoints on the 5 year follow‐up were all‐cause mortality and a composite of mayor cardiovascular adverse events (MACE).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In 379 patients, the presence of CAD and its complexity were not significantly associated with worse 5‐year survival after TAVI, with a mortality for SS0 of 45%; for SS 1–22 of 36.5% (HR 0.77; 95% CI 0.53–1.11, <jats:italic>p</jats:italic> = 0.15) and for SS > 22 of 42.1% (HR 1.24; 95% CI 0.59–2.63, <jats:italic>p</jats:italic> = 0.57). Regarding the combined event of MACE, there were also no statistically significant differences between patients with CAD and without CAD (56.8% in patients without CAD and 54.9% in patients with CAD; HR 1.06; 95% CI 0.79–1.43, <jats:italic>p</jats:italic> = 0.7). Angiography‐guided PCI or completeness of revascularization was not associated with different outcomes.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In the present analysis, neither the presence nor the extent of CAD, nor the degree of revascularization, was associated with a prognostic impact in patients undergoing TAVI at 5‐year follow‐up.</jats:p></jats:sec>