Beschreibung:
AbstractCurrent research in radiopharmaceutical chemistry is aimed at the design of technetium‐based receptor‐binding radiotracers because of the excellent nuclide properties of the isotope 99mTc. Tc tracers and the corresponding complexes of rhenium, as the inactive surrogate of Tc, are required to imitate organic agonists or antagonists of the receptor. We have started studies with ergolines, which are known to be dopamine substitutes. The present report deals with the functionalization of 8α‐amino‐6‐methyl‐ergoline (2) with a 2‐mercaptoacetyl group, and the subsequent synthesis of the first rhenium complex containing a pendent ergoline moiety [Re‐ O(SSS)(RS)] (HSSSH = HS‐CH2CH2‐S‐CH2CH2‐SH and RSH = 8a‐amino‐N‐(2‐mercaptoacetyl)‐6‐methyl‐ergoline) (4). The molecular structure of the rhenium complex was determined by X‐ray crystal structure analysis.