Chemoenzymatic and microbial dynamic kinetic resolutions

Medientyp: E-Artikel
Titel: Chemoenzymatic and microbial dynamic kinetic resolutions
Beteiligte: Kamaruddin, Azlina Harun; Uzir, Mohamad Hekarl; Aboul‐Enein, Hassan Y.; Halim, Hairul Nazirah Abdul
Erschienen: Wiley, 2009
Erschienen in: Chirality
Sprache: Englisch
DOI: 10.1002/chir.20619
ISSN: 1520-636X; 0899-0042
Schlagwörter: Organic Chemistry ; Spectroscopy ; Drug Discovery ; Pharmacology ; Catalysis ; Analytical Chemistry
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Beschreibung: <jats:title>Abstract</jats:title><jats:p>This review tracks a decade of dynamic kinetic resolution developments with a biocatalytic inclination using enzymatic/microbial means for the resolution part followed by the racemization reactions either by means of enzymatic or chemocatalyst. These fast developments are due to the ability of the biocatalysts to significantly reduce the number of synthetic steps which are common for conventional synthesis. Future developments in novel reactions and products of dynamic kinetic resolutions should consider factors that are needed to be extracted at the early synthetic stage to avoid inhibition at scale‐up stage have been highlighted. Chirality, 2009. © 2008 Wiley‐Liss, Inc.</jats:p>

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