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Medientyp:
E-Artikel
Titel:
Redispersion of Nanoparticle‐Loaded Orodispersible Films: Preservation of Particle Fineness
Beteiligte:
Steiner, Denise;
Finke, Jan Henrik;
Kwade, Arno
Erschienen:
Wiley, 2017
Erschienen in:
Chemie Ingenieur Technik, 89 (2017) 8, Seite 1034-1040
Sprache:
Englisch
DOI:
10.1002/cite.201600139
ISSN:
0009-286X;
1522-2640
Entstehung:
Anmerkungen:
Beschreibung:
AbstractThe application of orodispersible films (ODFs) as carrier for drug nanoparticles was discovered a few years ago. Poorly water‐soluble drugs are milled to nanosuspensions to improve their bioavailability. During the manufacturing process they are embedded into a polymer matrix or loaded on the surface of drug‐free ODF templates. The particle size of the particles released from the ODF was measured when redispersed in water. A preservation of the drug particle sizes could be achieved for both investigated ODF types when an adequate amount of matrix material is added to prevent agglomeration during the drying process.