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Teragawa, Hiroki; Ueda, Kentaro; Okuhara, Koichiro; Kuwashima, Rieko; Fukuda, Yukihiro; Kiguchi, Masao; Taniguchi, Kingo; Higashi, Yukihito; Oshima, Tetsuya; Yoshizumi, Masao; Chayama, Kazuaki

Coronary Vasospasm Produces Reversible Perfusion Defects Observed During Adenosine Triphosphate Stress Myocardial Single‐photon Emission Computed Tomography

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  • Medientyp: E-Artikel
  • Titel: Coronary Vasospasm Produces Reversible Perfusion Defects Observed During Adenosine Triphosphate Stress Myocardial Single‐photon Emission Computed Tomography
  • Beteiligte: Teragawa, Hiroki; Ueda, Kentaro; Okuhara, Koichiro; Kuwashima, Rieko; Fukuda, Yukihiro; Kiguchi, Masao; Taniguchi, Kingo; Higashi, Yukihito; Oshima, Tetsuya; Yoshizumi, Masao; Chayama, Kazuaki
  • Erschienen: Wiley, 2008
  • Erschienen in: Clinical Cardiology, 31 (2008) 7, Seite 310-316
  • Sprache: Englisch
  • DOI: 10.1002/clc.20217
  • ISSN: 0160-9289; 1932-8737
  • Entstehung:
  • Hochschulschrift:
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  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Adenosine triphosphate stress thallium‐201 single‐photon emission computed tomography (ATP‐SPECT) is useful for diagnosing coronary artery disease (CAD), although sometimes false positive results are observed. It has not been established whether a coronary spasm is responsible for the false positive findings during ATP‐SPECT.</jats:p></jats:sec><jats:sec><jats:title>Hypothesis</jats:title><jats:p>We investigated whether coronary spasm is one of the factors which produces reversible defects on ATP‐SPECT.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Eighty‐six patients (mean age: 62 y; 58 men) who underwent both spasm‐provocation testing by coronary angiography and ATP‐SPECT, were selected for the study. Patients with coronary narrowing (&gt;30%), myocardial infarction, or heart failure were excluded. Patients were divided into 2 groups based on whether the spasm‐provocation test result was positive (vasospastic angina [VSA] group, n = 46) or negative (non‐VSA group, n = 39).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The body mass index was lower in the VSA group than in the non‐VSA group (p = 0.005). On ATP‐SPECT imaging, any type of reversible defect was observed more frequently in the VSA group (68%) than in the non‐VSA group (36%, p = 0.0027). Logistic regression analysis demonstrated that the presence of reversible defects was one of the factors accounting for the presence of coronary vasospasm (p = 0.0022, R<jats:sup>2</jats:sup> = 0.172).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The findings suggest that reversible defects on ATP‐SPECT imaging are frequently present in patients with coronary vasospasm. Coronary spasm may be considered as 1 of the factors, which produce reversible defects on ATP‐SPECT, observed in patients with chest symptoms and angiographically normal coronary arteries. Copyright © 2008 Wiley Periodicals, Inc.</jats:p></jats:sec>
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